amakuru

Iyo dihydrotanshinone I yishe Helicobacter pylori, ntishobora kwangiza biofilm gusa, ahubwo ishobora no kwica bagiteri zifatanije na biofilm, igira uruhare mukurandura pylori ya Helicobacter.

Bi Hongkai, Porofeseri, Ishuri ry'Ubuvuzi Bwibanze, Kaminuza y'Ubuvuzi ya Nanjing

Amakuru aheruka ya kanseri ku isi yerekana ko mu bantu miliyoni 4.57 banduye kanseri mu Bushinwa buri mwaka, 480.000 banduye kanseri yo mu gifu, bangana na 10.8%, bari muri batatu ba mbere. Mu Bushinwa hagaragaramo kanseri yo mu gifu, umubare w’ubwandu bwa Helicobacter pylori uri hejuru ya 50%, kandi ikibazo cyo kurwanya antibiyotike kigenda kirushaho gukomera, bigatuma igabanuka rikomeza kugabanuka.
Vuba aha, itsinda rya Porofeseri Bi Hongkai, Ishuri ry’Ubuvuzi bw’ibanze, Kaminuza y’Ubuvuzi ya Nanjing, ryagaragaje neza umukandida mushya w’ibiyobyabwenge kuri Helicobacter pylori-Dihydrotanshinone I. Dihydrotanshinone I mfite ibyiza byo gukora neza no kwica byihuse Helicobacter pylori, anti - Helicobacter pylori biofilm, umutekano no kurwanya kurwanya, nibindi, kandi biteganijwe ko azinjira mubushakashatsi bwibanze nkumukandida w’ibiyobyabwenge birwanya Helicobacter. Ibisubizo byatangajwe kumurongo mu kinyamakuru mpuzamahanga cyemewe cya mikorobe “Antimicrobial Agents and Chemotherapy”.

Igipimo cyambere cyo kunanirwa kuvura gakondo ni hafi 10%

Munsi ya microscope, uburebure ni micrometero 2,5 kugeza kuri micrometero 4, naho ubugari ni micrometero 0,5 kugeza kuri micrometero 1. Helicobacter pylori, bagiteri yagoramye izunguruka "ikwirakwiza amenyo ikabyina inzara", ntishobora gutera gusa gastrite ikaze kandi idakira, ibisebe byo mu gifu na duodenal na lymphatics. Indwara nka lymphoma yo mu gifu ikwirakwizwa na kanseri ifata kanseri yo mu gifu, kanseri y'umwijima, na diyabete.

Ubuvuzi butatu na kane burimo antibiyotike ebyiri zikoreshwa cyane mugihugu cyanjye kuvura Helicobacter pylori, ariko uburyo bwo kuvura gakondo ntibushobora gukuraho pylori ya Helicobacter.

Ati: “Ikigereranyo cyo kunanirwa kuvura bwa mbere bwo kuvura gakondo ni 10%. Bamwe mu barwayi bazagira impiswi cyangwa indwara ya gastrointestinal flora. Abandi ni allergique kuri penisiline, kandi hariho antibiyotike nkeya guhitamo. Muri icyo gihe kandi, gukoresha antibiyotike igihe kirekire bizatera bagiteri Iterambere ryo kurwanya ibiyobyabwenge rituma antibiyotike ikora nabi, kandi ingaruka zo kurandura ntizishobora kugerwaho na gato. ” Bi Hongkai yagize ati: “Bagiteri irwanya antibiyotike zimwe na zimwe, kandi izanarwanya izindi antibiyotike, kandi izirwanya nazo zirashobora gutandukana mu buryo butandukanye. Indwara ya bagiteri ikwirakwira binyuze mu ngirabuzimafatizo zirwanya ibiyobyabwenge, ibyo bikaba bigoye kurwanya imiti ya bagiteri. ”

Iyo Helicobacter pylori irwanya igitero cy’abanzi, izagira amayeri ikora biofilm “igifuniko cyo gukingira” ubwayo, kandi biofilm izaba ifite kurwanya antibiyotike, bikaviramo kwiyongera kurwanya pylori ya Helicobacter, bikagira ingaruka ku buvuzi no kugabanya igipimo cy’umuti.

Saliviya miltiorrhiza ikuramo ingirabuzimafatizo irashobora kubuza imiti myinshi irwanya ibiyobyabwenge

Mu 1994, Ishami ry'Umuryango w'Abibumbye ryita ku Buzima ryashyize Helicobacter pylori nka kanseri yo mu cyiciro cya mbere kuko igira uruhare runini mu kubaho no gutera kanseri yo mu gifu. Nigute dushobora kurandura uyu mwicanyi wubuzima? Muri 2017, itsinda rya Bi Hongkai ryateye intambwe binyuze mubushakashatsi bwibanze-Danshen.

Danshen ni umwe mu miti gakondo ikoreshwa cyane mu Bushinwa mu guteza imbere umuvuduko w'amaraso no gukuraho amaraso. Ibikomoka ku binure byamavuta ni ibibyimba bya tanshinone, harimo monomer zirenga 30 nka tanshinone I, dihydrotanshinone, tanshinone IIA, na cryptotanshinone. Ibikoresho bya Tanshinone bifite ingaruka zitandukanye za farumasi, nka anti-kanseri, bagiteri-anti-positif, anti-inflammatory, ibikorwa bisa na estrogene ndetse no kurinda umutima-mitsi, nibindi, ariko ingaruka zo kurwanya Helicobacter pylori ntizigeze zitangazwa.

Ati: “Mbere, twasuzumaga imiti isaga 1.000 yo mu Bushinwa ku rwego rw'akagari, hanyuma amaherezo twemeza ko monomer ya dihydrotanshinone I i Danshen yagize ingaruka nziza mu kwica pylori ya Helicobacter. Mugihe dukora ubushakashatsi bwakagari, twasanze mugihe intumbero ya dihydrotanshinone nakoreshejwe Iyo ari 0.125 μg / ml-0.5 μg / ml, irashobora kubuza imikurire yimiterere myinshi ya Helicobacter pylori, harimo antibiyotike-yangiza imiti myinshi. . ” Bi Hongkai yavuze ko dihydrotanshinone I nayo ifite akamaro kanini kurwanya Helicobacter pylori muri biofilm. Ingaruka nziza yo kwica, na Helicobacter pylori ntabwo yateje imbere kurwanya dihydrotanshinone I mugihe gikomeza.

Igitangaje kinini ni uko "Iyo dihydrotanshinone I yishe Helicobacter pylori, ntishobora kwangiza biofilm gusa, ahubwo ishobora no kwica bagiteri zifatanije na biofilm, igira uruhare mu 'kurandura' pylori ya Helicobacter. “Bi Hongkai yerekanye.

Dihydrotanshinone nshobora gukiza Helicobacter pylori?

Kugirango ibisubizo byubushakashatsi birusheho kuba byiza, itsinda rya Bi Hongkai ryanakoze ubushakashatsi bwo gusuzuma imbeba kugirango barusheho kumenya ingaruka zica dihydrotanshinone I kuri pylori ya Helicobacter.

Bi Hongkai yerekanye ko muri ubwo bushakashatsi, nyuma y'ibyumweru bibiri imbeba zanduye Helicobacter pylori, abashakashatsi babigabanyijemo amatsinda 3, aribwo itsinda ry’ubuyobozi bwahurijwe hamwe na omeprazole na dihydrotanshinone I, itsinda ry’ubuyobozi bukuru bwa gatatu, hamwe na aside fosifori Muri itsinda rishinzwe kugenzura buffer, imbeba zahawe imiti rimwe kumunsi iminsi 3 ikurikiranye.

Ati: "Ibisubizo by'ubushakashatsi byerekana ko itsinda ry’ubuyobozi bwa omeprazole na dihydrotanshinone I rifite ubushobozi bwo kwica pylori ya Helicobacter kuruta itsinda risanzwe rya gatatu." Bi Hongkai yavuze, bivuze ko mu mbeba, dihydrotanshinone mfite ubushobozi bwo kwica kurusha ibiyobyabwenge gakondo.

Ni ryari Dihydrotanshinone nzinjira mumazu yabantu basanzwe? Bi Hongkai yashimangiye ko Danshen idashobora gukoreshwa mu buryo butaziguye mu gukumira no kuvura indwara ya Helicobacter pylori, kandi monomer dihydrotanshinone ya I ikiri kure yo gukorwa mu biyobyabwenge bishobora gukoreshwa mu mavuriro. Yavuze ko intambwe ikurikira izakomeza kwiga uburyo bwo gukora dihydrotanshinone I, no kunoza imiti n’uburozi bwa dihydrotanshinone I kurwanya Helicobacter pylori. “Inzira iri imbere iracyari ndende. Ndizera ko ibigo bishobora kugira uruhare mu bushakashatsi bwakozwe mbere y’ubuvuzi kandi bigakomeza ubu bushakashatsi kugira ngo bigirire akamaro abarwayi benshi barwaye igifu. ”